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Sakthivel Sadayappan Selected Research

Actomyosin

1/2021Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.
1/2019MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.

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Sakthivel Sadayappan Research Topics

Disease

26Heart Failure
05/2024 - 02/2009
13Myocardial Infarction
01/2022 - 05/2010
11Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
01/2023 - 01/2012
10Cardiomyopathies (Cardiomyopathy)
01/2023 - 02/2009
5Reperfusion Injury
01/2020 - 04/2009
4Heart Diseases (Heart Disease)
05/2024 - 01/2014
4Cardiovascular Diseases (Cardiovascular Disease)
01/2022 - 11/2017
3Inflammation (Inflammations)
01/2023 - 02/2020
3Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2022 - 01/2019
3Hypertrophy
02/2020 - 07/2012
3Fibrosis (Cirrhosis)
02/2020 - 07/2014
2Pancreatic Neoplasms (Pancreatic Cancer)
09/2023 - 03/2023
2Adenocarcinoma
09/2023 - 03/2023
2Arthrogryposis
01/2023 - 01/2021
2Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2022 - 01/2012
2Cardiac Arrhythmias (Arrythmia)
06/2021 - 01/2020
2Neoplasms (Cancer)
12/2020 - 01/2019
2Myocardial Ischemia (Ischemic Heart Diseases)
02/2020 - 01/2012
2Infarction (Infarctions)
01/2019 - 08/2014
2Cardiomegaly (Heart Hypertrophy)
07/2012 - 05/2006
1Marfan Syndrome (Marfan's Syndrome)
01/2024
1Cardiovascular Abnormalities
01/2024
1Contracture
01/2023
1Cardiac Sudden Death (Sudden Cardiac Arrest)
01/2023
1Type 2 Diabetes Mellitus (MODY)
01/2022
1Hyperglycemia
01/2022
1Hyperinsulinism (Hyperinsulinemia)
01/2022
1Hyperlipidemias (Hyperlipidemia)
01/2022
1Obesity
01/2022
1Muscular Diseases (Myopathy)
01/2021
1Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
01/2021
1Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
01/2021
1Mitochondrial Diseases (Mitochondrial Disease)
01/2021
1Polyneuropathies (Polyneuropathy)
01/2021
1Bethlem myopathy
01/2021
1Cardiotoxicity
12/2020
1Left Ventricular Outflow Obstruction
02/2020
1Aneurysm (Aneurysms)
02/2020
1Thrombosis (Thrombus)
02/2020
1Ischemia
01/2019

Drug/Important Bio-Agent (IBA)

21Proteins (Proteins, Gene)FDA Link
05/2024 - 05/2010
20Carrier Proteins (Binding Protein)IBA
01/2022 - 02/2009
20Cardiac MyosinsIBA
01/2022 - 02/2009
8Biomarkers (Surrogate Marker)IBA
06/2021 - 05/2010
5CalciumIBA
06/2021 - 01/2014
3salicylhydroxamic acid (SHAM)IBA
01/2022 - 04/2013
3ChromatinIBA
01/2022 - 02/2020
3Myosins (Myosin)IBA
01/2022 - 01/2019
3Protein Isoforms (Isoforms)IBA
12/2017 - 05/2006
2phospholambanIBA
01/2023 - 06/2021
2LipocalinsIBA
01/2023 - 01/2022
2CytokinesIBA
01/2022 - 07/2012
2Phosphotransferases (Kinase)IBA
01/2022 - 01/2019
2Contractile ProteinsIBA
01/2022 - 08/2007
2DNA (Deoxyribonucleic Acid)IBA
01/2021 - 01/2020
2ActomyosinIBA
01/2021 - 01/2019
2Indicators and Reagents (Reagents)IBA
11/2017 - 08/2013
2Adrenergic Agents (Adrenergic Drugs)IBA
05/2015 - 04/2013
1myosin-binding protein CIBA
05/2024
1Fibrillin-1IBA
01/2024
1omecamtiv mecarbilIBA
01/2023
1Arginine (L-Arginine)FDA Link
01/2023
1Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA
01/2023
1Therapeutic UsesIBA
01/2023
1Troponin T (Troponin T1)IBA
01/2023
1LipopolysaccharidesIBA
01/2023
1amsonic acid (DAS)IBA
01/2023
1EndotoxinsIBA
01/2023
1Adenosine Triphosphatases (ATPase)IBA
01/2022
1LipidsIBA
01/2022
1Peptides (Polypeptides)IBA
01/2022
1Messenger RNA (mRNA)IBA
01/2022
1Serine (L-Serine)FDA Link
01/2022
1ChemokinesIBA
01/2022
1Untranslated RNA (Noncoding RNA)IBA
01/2021
1Valosin Containing ProteinIBA
01/2021
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
01/2021
1Monoclonal AntibodiesIBA
12/2020
1Histones (Histone)IBA
02/2020
1Chymases (Chymase)IBA
02/2020
1AldosteroneIBA
01/2020
1von Willebrand FactorIBA
01/2020
1Eosine Yellowish-(YS) (Eosin)IBA
12/2019
1CalpainIBA
01/2019
15-ethynyl-2'-deoxyuridineIBA
01/2019
1Staphylococcal Protein A (Protein A)IBA
01/2019
15-Methylcytosine (5 Methylcytosine)IBA
01/2019
1Small Interfering RNA (siRNA)IBA
01/2019
15-hydroxymethylcytosineIBA
01/2019
1HydrogelsIBA
01/2019
1Probenecid (Benemid)FDA LinkGeneric
01/2018
1Troponin IIBA
12/2017
1Caspase 3 (Caspase-3)IBA
12/2017

Therapy/Procedure

5Therapeutics
05/2024 - 07/2012
2Drug Therapy (Chemotherapy)
09/2023 - 03/2023
1Ligation
01/2023
1Punctures
01/2023
1Immunotherapy
12/2020
1Rejuvenation
01/2020
1Cell- and Tissue-Based Therapy (Cell Therapy)
01/2020